Table 1 Characteristics of included studies
From: The impact of ketamine on emergency rapid sequence intubation: a systematic review and meta-analysis
Author | Year | Study design | Country | Main diagnosis | Number of patients | Number (%) women | Mean age (years) | Drugs | Neuromuscularar relaxants | Intubation location | ||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
Treatment | Control | Treatment | Control | Treatment | ||||||||
April | 2020 | RCT | USA | Trauma | 738 | 6068 | 2270 (33) | 49 | Ketamine | Etomidate | Rocuronium, Succinylcholine, Vecuronium | ED |
Baekgaard | 2020 | Cohort | Denmark | Trauma | 111 | 155 | 69 (26) | 49 | Ketamine | Mixed (Etomidate, propofol, or midazolam) | Rocuronium, Suxamethonium, Vecuronium | Pre-hospital & Trauma Center |
Breindahl | 2021 | Cohort | Denmark | Trauma | 228 | 320 | 137 (25) | 50 | Ketamine | Propofol | Rocuronium, Suxamethonium, or combined | Pre-hospital & Trauma Center |
Cornelius | 2018 | Cohort | USA | Trauma | 15 | 47 | NA | 46 | Ketamine | Etomidate | NA | Pre-hospital |
Edalatkhah (E) | 2021 | Cohort | Iran | COVID-19 | 8 | 12 | 6 (30) | 62 | Ketamine | Etomidate | NA | Inpatient |
Edalatkhah (M) | 2021 | Cohort | Iran | COVID-19 | 8 | 35 | 14 (33) | 67 | Ketamine | Midazolam | NA | Inpatient |
Edalatkhah (T) | 2021 | Cohort | Iran | COVID-19 | 8 | 21 | 11 (38) | 60 | Ketamine | Sodium thiopental | NA | Inpatient |
Foster | 2022 | Cohort | USA | NA | 86 | 272 | 110 (31) | 56 | Ketamine | Etomidate | Rocuronium, Succinylcholine | ED |
Jabre | 2009 | RCT | USA | Trauma | 235 | 234 | NA | 58 | Ketamine | Etomidate | Succinylcholine | ED |
Kim | 2023 | Cohort | Korea | Trauma | 118 | 354 | 105 (17) | 51 | Ketamine | Etomidate | NA | Trauma bay |
Knack | 2023 | RCT | USA | Medical | 70 | 73 | 52 (36) | 49 | Ketamine | Etomidate | Rocuronium, Succinylcholine | ED |
Leede (E) | 2021 | Cohort | USA | Trauma | 169 | 1786 | 427 (22) | 43 | Ketamine | Etomidate | NA | ED |
Leede (P) | 2021 | Cohort | USA | Trauma | 169 | 137 | 51 (17) | 40 | Ketamine | Propofol | NA | ED |
Lyon | 2015 | Cohort | UK | Trauma | 145 | 116 | 44 (19) | 42 | Ketamine | Etomidate | Rocuronium | Pre-hospital |
Matchett | 2021 | RCT | USA | Shock | 395 | 396 | 303 (38) | 56 | Ketamine | Etomidate | Rocuronium, Succinylcholine | ED |
Srivilaithon | 2023 | RCT | Thailand | Sepsis | 130 | 130 | 107 (41) | 72 | Ketamine | Etomidate | Succinylcholine | ED |
Upchurch | 2017 | Cohort | USA | Trauma | 442 | 526 | 261 (27) | 40 | Ketamine | Etomidate | Succinylcholine | ED |
Van | 2017 | Cohort | USA | Respiratory failure | 115 | 115 | 109 (47) | 60 | Ketamine | Etomidate | NA | Medical ICU |