Variable* | PH adults N = 687 | Post-ED adults N = 352 | p-value |
---|---|---|---|
Time from hospital discharge/ED attendance to follow-up appointment (days) | 61 (52–83) N = 677 | 75 (55–106) N = 347 | < 0.001 |
Time from onset of symptoms to time of follow-up appointment (days) | 69 (59–92) N = 604 | 85 (66–112) N = 304 | < 0.001 |
Long-COVID symptom burden at follow-up | |||
Abdominal pain | 5.1% N = 34/671 | 5.5% 19/346 | 0.77 |
Anorexia | 5.1% N = 34/671 | 4.0% N = 14/346 | 0.47 |
Anosmia | 8.8% N = 59/671 | 6.6% N = 23/346 | 0.23 |
Breathlessness | 16.6% N = 104/628 | 13.7% N = 6/336 | 0.24 |
Chest pain | 7.6% N = 51/672 | 9.0% N = 31/346 | 0.45 |
Chest tightness | 11.2% N = 75/671 | 11.6% N = 40/346 | 0.86 |
Confusion | 13.0% N = 87/671 | 9.6% N = 33/345 | 0.11 |
Cough | 22.2% N = 138/623 | 17.3% N = 58/336 | 0.07 |
Diarrhoea | 4.2% N = 28/671 | 4.0% N = 14/346 | 0.92 |
Fatigue | 11.9% N = 74/622 | 8.0% N = 27/337 | 0.06 |
Focal weakness | 10.1% N = 68/672 | 7.5% N = 26/346 | 0.17 |
Myalgia | 19.1% N = 128/671 | 17.1% N = 59/345 | 0.44 |
Peripheral oedema | 10.0% N = 67/671 | 4.3% N = 15/346 | 0.002 |
Sleep quality decrease | 29.2% N = 179/612 | 28.2% N = 93/330 | 0.73 |
Any 1 of 14 Long-COVID symptoms at follow-up | 79.5% N = 534/672 | 70.1% N = 242/345 | < 0.001 |
Total number of symptoms at follow-up | 2 (1–4) N = 675 | 2 (0–4) N = 346 | < 0.001 |
Mental health burden | |||
Depressive symptoms highlighted by a Patient Health Questionnaire-2 (PHQ-2) score ≥ 2 | 19.9% N = 129/647 | 19.1% N = 65/341 | 0.74 |
Post-traumatic stress symptoms highlighted by a Trauma Screening Questionnaire (TSQ) score ≥ 6 | 6.3% N = 38/604 | 3.5% N = 12/345 | 0.06 |
Functional recovery | |||
Patients reporting feeling back to normal | 60.9% N = 271/445 | 74.7% N = 163/218 | 0.001 |
Patients reporting recovery as 0-100 on VAS scale (with 100 reflecting best recovery) | 90 (70–99) N = 614 | 90 (75–100) N = 330 | 0.006 |
Number of patients back to work: | |||
Yes | 29.4% N = 190/647 | 46.1% N = 155/336 | < 0.001 |
No | 23.8% N = 154/647 | 20.5% N = 69/336 | |
Not applicable | 46.8% N = 303/647 | 33.3% N = 112/336 | |
Radiology | |||
Chest X-Ray result: | |||
Normal | 67.9% N = 399/588 | 79.4% N = 201/253 | < 0.001 |
Significantly improved (PCVCX1) | 20.4% N = 120/588 | 15.8% N = 40/253 | |
Specialty Care Referral (SCR) | |||
Any 1 of 4 Referrals (respiratory/cardiology/physiotherapy/mental health) | 25.0% N = 156/625 | 32.6% N = 114/350 | 0.011 |
Respiratory Referrals | 10.2% N = 63/619 | 8.9% N = 31/350 | 0.51 |
Cardiology Referrals | 10.9% N = 68/626 | 9.1% N = 32/351 | 0.39 |
Physiotherapy Referrals for exercise rehabilitation and/or management of dysfunctional breathing | 7.5% N = 41/626 | 14.2% N = 50/351 | 0.001 |
Mental Health referrals | 9.0% N = 56/625 | 15.1% N = 53/351 | 0.003 |
Neurology Referrals | 0.2% N = 1/626 | 0.0% N = 0/351 | 0.46 |
Referrals To Chronic Fatigue Services | 0.3% N = 2/626 | 0.0% N = 0/351 | 0.30 |
Memory Clinic Referrals | 0.5% N = 3/626 | 0.0% N = 0/351 | 0.20 |